Feb 13, 2025 1:12:30 PM
The dry milling step, also referred to as the calibration phase, follows the..
Manufacturing pharmaceutical OSD products presents a range of challenges and considerations when deciding on the process and equipment required. Patient-centric solutions are increasing in demand, so in order for manufacturers to maintain a competitive edge they need to product high quality end-products with increased bioavailability, improved flavor and mouthfeel, longer shelf life and enhanced solubility.
The OSD processes must be robust, cost-effective and flexible in order to maintain a competitive advantage. To achieve this, the equipment selected for the process should provide a good return on investment by minimizing downtime and waste so as to improve efficiency and keep costs down.
Alongside this, the production process must comply with regulatory guidelines, with current good manufacturing practice (CGMP), to ensure consistent quality and safety of the product. This includes eliminating risks such as contamination and inconsistencies in ingredients.
The ability to produce a tight particle size distribution suitable for tablet compression, compaction and dissolution is dependent upon selecting the right technology for the application. That's why we pay attention to how to control the powder condition and offer advice on key equipment elements such as tooling, impeller speed and RPM control, feeding method, surface finishes and cleaning solutions.
Quadro® mills provide unequalled particle processing efficiencies to enable pharmaceutical manufacturers to achieve their target PSDs and to manufacture their product with higher capacities. We aim to improve product quality by ensuring that the OSD powder is correctly conditioned for successful compression into tablets.
We offer products from lab scale to full production scale, with enhancements that enable effective handling of heat sensitive materials, high capacity mills and greaseless gearboxes that reduce the risk of contamination.
For almost 50 years, Quadro has been continually refining and improving our milling and sizing technology. During this time, we have become trusted partners of our customers around the world, offering solutions in a variety of drug therapy areas to achieve increased productivity, versatility and reliability.
Our extensive experience in providing solutions for OSD Pharma manufacturing includes supporting customers with their wet granulation process to produce a well-conditioned powder ready for tablet compression. But if dry granulation is your methodology we can also offer solutions to optimise the process.
We understand how the Particle Size Distribution (PSD) and bulk density of powders impact flowability to the tablet press and subsequent dissolution rate & bioavailability of the finished tablet. That's why our equipment is particularly well-known for achieving PSDs that are optimized to produce the correct level of compressibility for the tableting process.
When you invest in Quadro® OSD Pharma Milling Equipment, you get more than just superior engineering and quality, you get access to our team of experts who will ensure you achieve your objectives.
No matter what your application, our mills consistently deliver the batch-to-batch repeatability required to comply with the most demanding FDA standards. We adhere to ethical business principles and are committed to providing products of exceptional quality and value.
Patented worldwide, our products are designed and manufactured to the highest standards of materials, finish and performance in sanitary equipment design.
Our pharmaceutical processing experts can help you solve your size-reduction challenges, whilst meeting the strictest quality control standards of the industry.
Our equipment is renowned for delivering Particle Size Distributions (PSDs) that are precisely tailored to achieve the ideal compressibility for the tableting process.
Benefits from decades of exceptional engineering and quality and support from our expert team - get in touch today.
With decades of experience, we have expertise in providing a range of powder processing and sizing solutions for manufacturing APIs. Our team can help you find the right milling and sizing equipment for your application.
When you invest in Quadro® Pharma Milling Equipment, you get more than just superior engineering and quality, you also get access to our team of experts around the world, who will ensure you achieve your production objectives.
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